Herpes simplex lesions are typically located on which of the following?

Herpes simplex lesions are indeed commonly found on mucous membranes, which is why this answer is correct. The herpes simplex virus (HSV) typically affects areas where mucous membranes are present, such as the mouth, lips, and genital regions. This characteristic of the virus contributes to its transmission and manifestation, as these areas provide an environment conducive to the virus’s replication.

Mucous membranes are key sites for both HSV-1, which is primarily associated with oral herpes, and HSV-2, primarily linked with genital herpes. The lesions can appear as painful blisters that eventually crust over, making them distinct.

The other options, while containing some accurate elements, do not capture the primary site of the lesions as effectively as "mucous membranes." For example, herpes lesions can occur around the nose and mouth, primarily in the case of HSV-1, but they are still categorized as affecting mucous membranes. Similarly, while lesions can appear in the genital area, this does not encompass all locations where herpes simplex can manifest, making the focus on mucous membranes a more encompassing choice.