Which condition is treated with systemic antibiotics in addition to localized heat applications and drainage?

The condition that is treated with systemic antibiotics in addition to localized heat applications and drainage is a carbuncle. A carbuncle is a cluster of interconnected furuncles, or boils, that often leads to a deeper infection in the skin and tissue. Because of its extent and the risk of systemic infection, systemic antibiotics are necessary to fight the infection effectively.

Localized heat application helps to increase blood flow to the area, which can aid in the immune response and promote drainage of pus, while drainage of the carbuncle is crucial to relieve pressure and remove infectious material.

In contrast, a furuncle, while also a painful infection, is typically treated with localized methods and may not require systemic antibiotics unless it becomes more widespread or complicated. Herpes zoster, caused by the varicella-zoster virus, generally requires antiviral medications rather than antibiotics, and subcutaneous is a term rather than a specific condition, making it unrelated to the treatment context provided.