Which of the following describes lymphedema?

Lymphedema is specifically defined as swelling that results from the accumulation of lymphatic fluid in the body's tissues. This condition occurs when the lymphatic system is compromised, either due to genetic factors, surgery, radiation, infection, or injury, leading to a blockage or damage to the lymphatic vessels. As a result, fluid that is normally drained through these vessels builds up, causing swelling primarily in the arms and legs, but it can occur in other parts of the body as well.

The other options describe different medical conditions. An autoimmune disease refers to conditions where the immune system mistakenly attacks the body’s own tissues, which is not the primary characteristic of lymphedema. Similarly, inflammatory diseases are characterized by an immune response that causes inflammation, but lymphedema itself is not primarily an inflammatory condition. Finally, profound fatigue is a symptom that might be associated with various medical conditions but does not describe lymphedema. Thus, option B accurately captures the essence of what lymphedema is.